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Literature summary for 3.1.7.6 extracted from

  • Tsai, S.C.; Gaylor, J.L.
    Testicular sterols. V. Preparation and partial purification of a microsomal prenol pyrophosphate pyrophophohydrolase (1966), J. Biol. Chem., 241, 4043-4050.
    View publication on PubMed
Search for more literature for 3.1.7.6

Activating Compound

Activating Compound Comment Organism Structure
ATP 0.93 mM, stimulates Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoic acid
-
 Rattus norvegicus
3',5'-cAMP
-
 Rattus norvegicus
arsenite 1 mM Rattus norvegicus
isopentenyl diphosphate competitive Rattus norvegicus
additional information no inhibition by 1 mM p-mercuribenzoate Rattus norvegicus
Plasma albumin
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.7 1.2 (2E,6E)-farnesyl diphosphate pH 8.8, 37°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ slight stimulation Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2E,6E)-farnesyl diphosphate + H2O Rattus norvegicus biosynthesis of acyclic sesquiterpenoids (2E,6E)-farnesol + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesyl diphosphate + H2O biosynthesis of acyclic sesquiterpenoids Rattus norvegicus (2E,6E)-farnesol + diphosphate
-
 ?
(2E,6E)-farnesyl diphosphate + H2O diphosphate is the major product, traces of phosphate. The amount of release of diphosphate is approximately equal to the amount of release of farnesol Rattus norvegicus (2E,6E)-farnesol + diphosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.8
-
-
 Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
8.5 9.1 pH 8.5: about 40% of maximal activity, pH 9.1: about 65% of maximal activity Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5.2
-
 isopentenyl diphosphate pH 8.8, 37°C Rattus norvegicus