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Literature summary for 3.1.6.8 extracted from
- Driving forces of protein association: the dimer-octamer equilibrium in arylsulfatase A (2002), Biophys. J., 83, 3066-3078.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cerebroside 3-sulfate + H2O | Homo sapiens | - |
cerebroside + sulfate | galactosyl ceramid | ? |  |
| cerebroside 3-sulfate + H2O | Homo sapiens | - |
cerebroside + sulfate | galactosyl ceramide | ? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P15289 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cerebroside 3-sulfate + H2O | - |
Homo sapiens | cerebroside + sulfate | galactosyl ceramid | ? | |
| cerebroside 3-sulfate + H2O | - |
Homo sapiens | cerebroside + sulfate | galactosyl ceramide | ? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | at pH above 6, the enzyme exists in solution as a dimer | Homo sapiens |
| More | The dimer-octamer equilibrium is regulated by the pH and may be explained by a switch function of Glu424. Glu424 in the conformation suitable for the intramolecular hydrogen bonds to Gln460. Glu424 in the conformation suitable for the intermolecular hydrogen bonds to Phe398 | Homo sapiens |
| octamer | at pH below 6, the enzyme exists in solution as octamer | Homo sapiens |
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