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Literature summary for 3.1.6.4 extracted from

  • Almeciga-Diaz, C.J.; Rueda-Paramo, M.A.; Espejo, A.J.; Echeverri, O.Y.; Montano, A.; Tomatsu, S.; Barrera, L.A.
    Effect of elongation factor 1alpha promoter and SUMF1 over in vitro expression of N-acetylgalactosamine-6-sulfate sulfatase (2008), Mol. Biol. Rep., 36, 1863-1870.
    View publication on PubMed
Search for more literature for 3.1.6.4

Activating Compound

Activating Compound Comment Organism Structure
additional information cotransfection with sulfatase modifying factor 1 shows an increment up to 2.6fold in GALNS activity, cells cotransfected with elongation factor 1alpha show GALNS activity continued to increase until day 8 postransfection Homo sapiens

Application

Application Comment Organism
medicine Morquio A is an autosomal recessive disease caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase, leading to the lysosomal accumulation of keratan-sulfate and chondroitin-6-sulfate Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl-beta-D-galactopyranoside-6-sulfate + H2O
-
 Homo sapiens 4-methylumbelliferyl-beta-D-galactopyranoside + sulfate
-
 ?
chondroitin-6-sulfate + H2O
-
 Homo sapiens chondroitin + sulfate
-
 ?
keratan sulfate + H2O
-
 Homo sapiens keratan + sulfate
-
 ?

Synonyms

Synonyms Comment Organism
GALNS
-
 Homo sapiens
N-acetylgalactosamine-6-sulfate sulfatase
-
 Homo sapiens