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Literature summary for 3.1.6.4 extracted from
- Human liver N-acetylgalactosamine 6-sulphatase. Purification and characterization (1991), Biochem. J., 279, 515-520.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cl- | - |
Homo sapiens |  |
| phosphate | - |
Homo sapiens | |
| SO42- | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0125 | - |
oligosaccharide substrate derived from chondroitin 6-sulfate | - |
Homo sapiens | |
| 0.05 | - |
oligosaccharide substrates derived from keratan sulfate | - |
Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 19000 | - |
x * 19000, x * 39000, x * 57000, the active enzyme contains either the 57000 Da polypeptide or disulfide-linked 39000 Da and 19000 Da polypeptides | Homo sapiens |
| 39000 | - |
x * 19000, x * 39000, x * 57000, the active enzyme contains either the 57000 Da polypeptide or disulfide-linked 39000 Da and 19000 Da polypeptides | Homo sapiens |
| 57000 | - |
x * 19000, x * 39000, x * 57000, the active enzyme contains either the 57000 Da polypeptide or disulfide-linked 39000 Da and 19000 Da polypeptides | Homo sapiens |
| 62000 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | enzyme is involved in lysosomal degradation of the glycosaminoglycans keratan sulfate and chondroitin 6-sulfate | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.11 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme is involved in lysosomal degradation of the glycosaminoglycans keratan sulfate and chondroitin 6-sulfate | Homo sapiens | ? | - |
? | |
| oligosaccharide substrate derived from chondroitin 6-sulfate + H2O | - |
Homo sapiens | ? | - |
? | |
| oligosaccharide substrates derived from keratan sulfate + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 19000, x * 39000, x * 57000, the active enzyme contains either the 57000 Da polypeptide or disulfide-linked 39000 Da and 19000 Da polypeptides | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 3.5 | 4 | 6-sulfated oligosaccharide substrates | Homo sapiens |
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Release 2023.1 (January 2023)
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