Literature summary for 3.1.6.2 extracted from

Horvath, A.; Nussbaumer, P.; Wolff, B.; Billich, A.
2-(1-adamantyl)-4-(thio)chromenone-6-carboxylic acids: potent reversible inhibitors of human steroid sulfatase (2004), J. Med. Chem., 47, 4268-4276.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(2-(1-adamantyl)-4-oxo-4H-chromen-6-yl)(oxo)acetic acid	-	Homo sapiens
(2-(1-adamantyl)-4-oxo-4H-chromen-6-yl)acetic acid	-	Homo sapiens
2-(1-adamantyl)-4-oxo-4H-chromen-6-yl sulfamate	-	Homo sapiens
2-(1-adamantyl)-4-oxo-4H-chromene-6-carbaldehyde	-	Homo sapiens
2-(1-adamantyl)-4-oxo-4H-chromene-6-carboxamide	-	Homo sapiens
2-(1-adamantyl)-4-oxo-4H-chromene-6-carboxylic acid	-	Homo sapiens
2-(1-adamantyl)-4-oxo-4H-thiochromen-6-yl sulfamate	-	Homo sapiens
2-(1-adamantyl)-4-oxo-4H-thiochromene-6-carbonitrile	-	Homo sapiens
2-(1-adamantyl)-4-oxo-4H-thiochromene-6-carboxylic acid	-	Homo sapiens
2-(1-adamantyl)-6-(hydroxymethyl)-4H-chromen-4-one	-	Homo sapiens
2-(1-adamantyl)-6-glycoloyl-4H-chromen-4-one	-	Homo sapiens
methyl 2-(1-adamantyl)-4-oxo-4H-chromene-6-carboxylate	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	native enzyme and recombinant enzyme from CHO cells	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0005	-	2-(1-adamantyl)-4-oxo-4H-chromene-6-carboxylic acid	-	Homo sapiens
0.00053	-	2-(1-adamantyl)-4-oxo-4H-thiochromene-6-carboxylic acid	-	Homo sapiens
0.0022	-	(2-(1-adamantyl)-4-oxo-4H-chromen-6-yl)(oxo)acetic acid	-	Homo sapiens
0.0032	-	2-(1-adamantyl)-6-glycoloyl-4H-chromen-4-one	-	Homo sapiens
0.02	-	2-(1-adamantyl)-4-oxo-4H-chromene-6-carbaldehyde	or above	Homo sapiens
0.032	-	2-(1-adamantyl)-6-(hydroxymethyl)-4H-chromen-4-one	-	Homo sapiens
0.05	-	methyl 2-(1-adamantyl)-4-oxo-4H-chromene-6-carboxylate	or above	Homo sapiens
0.05	-	2-(1-adamantyl)-4-oxo-4H-chromene-6-carboxamide	or above	Homo sapiens
0.05	-	(2-(1-adamantyl)-4-oxo-4H-chromen-6-yl)acetic acid	or above	Homo sapiens
0.05	-	2-(1-adamantyl)-4-oxo-4H-thiochromene-6-carbonitrile	or above	Homo sapiens

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Release 2023.1 (January 2023)