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Literature summary for 3.1.6.14 extracted from
- Neutralizing the anticoagulant activity of ultra-low-molecular-weight heparins using N-acetylglucosamine 6-sulfatase (2013), FEBS J., 280, 2523-2532.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | application of human N-acetylglucosamine 6-sulfatase, expressed in Chinese hamster ovary cells as a reversal agent for ultra-low molecular weight heparin. The enzyme removes a single 6-O-sulfo group at the non-reducing end of the ultra-low molecular weight heparin Arixtra (fondaparinux) effectively removing its ability to bind to antithrombin and preventing its inhibition of coagulation factor Xa | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NG6S | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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