BRENDA - Enzyme Database show
show all sequences of 3.1.6.13

Identification and partial characterization of two enzyme forms of iduronate sulfatase from human placenta

Di Natale, P.; Ronsisvalle, L.; Biochim. Biophys. Acta 661, 106-111 (1981)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
NaCl
-
Homo sapiens
phosphate
-
Homo sapiens
SO42-
-
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.013
-
O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate
form A
Homo sapiens
0.015
-
O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate
form B
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
lysosome
-
Homo sapiens
5764
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
80000
115000
form A, gel filtration, SDS-PAGE
Homo sapiens
81000
83000
form B, gel filtration
Homo sapiens
83000
94000
form A, sucrose density gradient centrifugation
Homo sapiens
170000
190000
form B, sucrose density gradient centrifugation
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
dermatan sulfate + H2O
Homo sapiens
-
dermatan + sulfate
-
-
?
heparan sulfate + H2O
Homo sapiens
-
dermatan + sulfate
-
-
?
heparin + H2O
Homo sapiens
-
desulfated heparin + sulfate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
2 forms: A, B
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
glycoprotein
contains sialic acid residues
Homo sapiens
Purification (Commentary)
Commentary
Organism
partial
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
placenta
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
dermatan sulfate + H2O
-
135566
Homo sapiens
dermatan + sulfate
-
-
-
?
heparan sulfate + H2O
-
135566
Homo sapiens
dermatan + sulfate
-
-
-
?
heparin + H2O
-
135566
Homo sapiens
desulfated heparin + sulfate
-
-
-
?
O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate + H2O
-
135566
Homo sapiens
O-(alpha-L-idopyranosyluronic acid)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate + sulfate
-
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
50
-
stable for 5 min
Homo sapiens
55
-
30 min, 50% loss of activity of form A, 45 min, 50% loss of activity of form B
Homo sapiens
64
-
5 min, 50% loss of activity
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
4
-
-
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
NaCl
-
Homo sapiens
phosphate
-
Homo sapiens
SO42-
-
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.013
-
O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate
form A
Homo sapiens
0.015
-
O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate
form B
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
lysosome
-
Homo sapiens
5764
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
80000
115000
form A, gel filtration, SDS-PAGE
Homo sapiens
81000
83000
form B, gel filtration
Homo sapiens
83000
94000
form A, sucrose density gradient centrifugation
Homo sapiens
170000
190000
form B, sucrose density gradient centrifugation
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
dermatan sulfate + H2O
Homo sapiens
-
dermatan + sulfate
-
-
?
heparan sulfate + H2O
Homo sapiens
-
dermatan + sulfate
-
-
?
heparin + H2O
Homo sapiens
-
desulfated heparin + sulfate
-
-
?
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
glycoprotein
contains sialic acid residues
Homo sapiens
Purification (Commentary) (protein specific)
Commentary
Organism
partial
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
placenta
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
dermatan sulfate + H2O
-
135566
Homo sapiens
dermatan + sulfate
-
-
-
?
heparan sulfate + H2O
-
135566
Homo sapiens
dermatan + sulfate
-
-
-
?
heparin + H2O
-
135566
Homo sapiens
desulfated heparin + sulfate
-
-
-
?
O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate + H2O
-
135566
Homo sapiens
O-(alpha-L-idopyranosyluronic acid)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate + sulfate
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
50
-
stable for 5 min
Homo sapiens
55
-
30 min, 50% loss of activity of form A, 45 min, 50% loss of activity of form B
Homo sapiens
64
-
5 min, 50% loss of activity
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
4
-
-
Homo sapiens
Other publictions for EC 3.1.6.13
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
730775
Zuber
The effect of recombinant huma ...
Homo sapiens
PLoS ONE
9
e85074
2014
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1
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2
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1
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-
-
-
-
730196
Morales-Alvarez
Low-scale expression and purif ...
Homo sapiens
J. Microbiol.
51
213-221
2013
-
1
1
-
-
-
-
-
-
-
1
-
-
5
-
-
1
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
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-
-
1
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-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714554
Lu
Expression in CHO cells and ph ...
Homo sapiens
Biotechnol. Bioeng.
108
1954-1964
2011
-
1
1
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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1
1
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1
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-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
715792
Sosa
Development of a sandwich enzy ...
Homo sapiens
J. Immunol. Methods
368
64-70
2011
-
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
2
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
707600
Lu
Genetic engineering of a bifun ...
Homo sapiens
Bioconjug. Chem.
21
151-156
2010
-
1
1
-
-
-
-
-
-
-
3
-
-
3
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
-
1
1
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-
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-
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-
-
3
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
1
1
-
-
-
708665
Lualdi
Enigmatic In Vivo iduronate-2- ...
Homo sapiens
Hum. Mutat.
31
E1261-E1285
2010
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
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1
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1
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-
-
1
-
-
-
-
-
-
-
-
-
2
1
1
2
-
-
709793
Moro
A novel functional role of idu ...
Danio rerio
Matrix Biol.
29
43-50
2010
-
1
1
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
14
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
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-
1
-
-
-
-
-
-
-
-
14
-
-
1
-
-
-
-
-
-
-
-
-
2
2
2
2
-
-
709973
Okuyama
Japan Elaprase Treatment (JET) ...
Homo sapiens
Mol. Genet. Metab.
99
18-25
2010
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
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-
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-
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1
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1
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-
-
-
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-
-
-
-
-
-
-
1
1
-
-
-
707017
Cordoba-Ruiz
-
Laboratory scale production of ...
Homo sapiens
Afr. J. Biotechnol.
8
1786-1792
2009
-
1
1
-
-
-
-
-
-
-
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1
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1
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1
1
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-
1
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-
-
-
-
-
-
-
1
1
1
1
-
-
707032
Polito
IDS crossing of the blood-brai ...
Homo sapiens
Am. J. Hum. Genet.
85
296-301
2009
-
1
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
1
-
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1
1
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1
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-
-
-
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-
2
1
1
2
-
-
707060
Piquer
Role of iduronate-2-sulfatase ...
Homo sapiens
Am. J. Physiol. Endocrinol. Metab.
297
E793-E801
2009
-
-
1
-
-
-
-
-
-
1
1
-
-
2
-
-
-
-
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1
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1
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1
1
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1
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-
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-
-
1
1
1
1
-
-
709386
Jones
Mortality and cause of death i ...
Homo sapiens
J. Inherit. Metab. Dis.
32
534-543
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
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-
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1
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-
-
1
1
-
-
-
709387
Schwartz
Clinical and biochemical studi ...
Homo sapiens
J. Inherit. Metab. Dis.
32
732-738
2009
-
1
-
-
-
-
-
-
-
-
-
-
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2
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-
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2
-
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1
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2
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-
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-
1
1
-
-
-
709970
Araya
Localized donor cells in brain ...
Homo sapiens
Mol. Genet. Metab.
98
255-263
2009
-
1
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
6
-
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1
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1
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6
-
-
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-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
710212
Muenzer
Multidisciplinary management o ...
Homo sapiens
Pediatrics
124
e1228-e1239
2009
-
1
-
-
-
-
-
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1
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3
-
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1
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1
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1
1
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-
691079
Friso
Gene therapy of Hunter syndrom ...
Mus musculus
Biochim. Biophys. Acta
1782
574-580
2008
-
-
-
-
-
-
-
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1
-
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4
-
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7
-
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3
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1
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7
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3
-
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-
691866
Lau
Molecular investigations of a ...
Homo sapiens
Clin. Chim. Acta
392
8-10
2008
-
-
1
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
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-
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-
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1
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4
-
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2
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-
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-
699379
Keeratichamroen
Molecular analysis of the idur ...
Homo sapiens
J. Inherit. Metab. Dis.
Suppl. 2
303-311
2008
-
-
1
-
10
-
-
-
-
-
-
-
-
2
-
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-
1
-
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3
-
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1
-
-
10
-
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-
-
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-
1
-
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3
-
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-
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-
-
-
-
675681
Bhattacharyya
Steroid sulfatase, arylsulfata ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
103
20-34
2007
-
-
-
-
-
-
-
-
-
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Characterization of a novel p. ...
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Dean
Detection of mucopolysaccharid ...
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679281
Lin
Detection of Hunter syndrome ( ...
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681228
Alves
Molecular characterization of ...
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Effect of Hunter disease (muco ...
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Multiple cryptic splice sites ...
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663953
Parkinson-Lawrence
Analysis of normal and mutant ...
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Identification of iduronate-2- ...
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Parkinson
Iduronate-2-sulphatase protein ...
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Kim
Mutational spectrum of the idu ...
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Daniele
Uptake of recombinant iduronat ...
Homo sapiens, Rattus norvegicus
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Bonuccelli
The effect of four mutations o ...
Homo sapiens
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650331
Villani
Expression of five iduronate-2 ...
Homo sapiens
Biochim. Biophys. Acta
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653245
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'Supercharged Cells' for deliv ...
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Mol. Genet. Metab.
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Characterization of iduronate ...
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Mucopolysaccharidosis type II ...
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Recombinant human iduronate-2- ...
Homo sapiens
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Bielicki
Human liver iduronate-2-sulpha ...
Homo sapiens
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8
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1
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135571
Di Natale
Iduronate sulfatase from human ...
Homo sapiens
Biochim. Biophys. Acta
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1
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135570
Lissens
Polyclonal antibodies against ...
Homo sapiens
Biochim. Biophys. Acta
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365-371
1984
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135567
Yutaka
Purification and some properti ...
Homo sapiens
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10
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2
1
1
4
-
1
-
1
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1
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135568
Wasteson
Iduronate sulfatase from human ...
Homo sapiens
Methods Enzymol.
83
573-578
1982
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3
2
1
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1
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3
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1
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1
3
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1
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2
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4
-
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1
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2
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135569
Archer
Multiple forms of iduronate 2- ...
Homo sapiens
Biochim. Biophys. Acta
708
134-140
1982
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1
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5
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4
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3
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3
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1
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5
-
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135566
Di Natale
Identification and partial cha ...
Homo sapiens
Biochim. Biophys. Acta
661
106-111
1981
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-
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3
2
1
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3
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4
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1
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3
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1
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3
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1
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3
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1
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4
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1
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135572
Constantopoulos
Experimental animal model for ...
Rattus norvegicus
Proc. Natl. Acad. Sci. USA
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3700-3704
1980
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1
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135573
Bach
The defect in the Hunter syndr ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
70
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1973
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Sjoberg
Hunter's syndrome: a deficienc ...
Homo sapiens
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54
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