Literature summary for 3.1.6.12 extracted from

Yogalingam, G.; Litjens, T.; Bielicki, J.; Crawley, A.C.; Muller, V.; Anson, D.S.; Hopwood, J.J.
Feline mucopolysaccharidosis type VI. Characterization of recombinant N-acetylgalactosamine 4-sulfatase and identification of a mutation causing the disease (1996), J. Biol. Chem., 271, 27259-27265.

Search for more literature for 3.1.6.12

Application

Application	Comment	Organism
medicine	enzyme replacement in MPS IV feline fibroblast	Felis catus

Cloned(Commentary)

Cloned (Comment)	Organism
-	Felis catus

Protein Variants

Protein Variants	Comment	Organism
L476P	mutation in MPS IV cats	Felis catus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
N-acetyl-D-galactosamine 4-sulfate units + H2O	Felis catus	acts also on N-acetylglucosamine 4-sulfate	N-acetyl-D-galactosamine units + sulfate	-	?

Organism

Organism	UniProt	Comment	Textmining
Felis catus	-	siamese cat, feline model of human Maroteaux-Lamy Syndrom	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Felis catus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-methylumbelliferyl sulfate + H2O	-	Felis catus	4-methylumbelliferone + sulfate	-	?
N-acetygalactosamine 4-sulfate-(1-4)-beta-glucuronic acid-(1-3)-beta-N-acetylgalactosaminitol 4-sulfate + H2O	-	Felis catus	N-acetygalactosamine-(1-4)-beta glucuronic acid-(1-3)-beta N-acetylgalactosaminitol 4-sulfate + sulfate	-	?
N-acetyl-D-galactosamine 4-sulfate units + H2O	acts also on N-acetylglucosamine 4-sulfate	Felis catus	N-acetyl-D-galactosamine units + sulfate	-	?

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Release 2023.1 (January 2023)