Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y3Z3 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
SAMHD1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enzyme is variably expressed during the cell cycle, maximally during quiescence and minimally during S-phase | additional information |
General Information | Comment | Organism |
---|---|---|
physiological function | treatment of lung or skin fibroblasts with enzyme-specific siRNA results in the disappearence of enzyme protein accompanied by loss of the cell-cycle regulation of dNTP pool sizes and dNTP imbalance. Cells accumulate in G1 phase with oversized pools and stopp growing. Following removal of the siRNA, the pools are normalized and cell growth restarted, but only after enzyme SAMHD1 has reappeared. In quiescent cultures SAMHD1 down-regulation leads to a marked expansion of dNTP pools. In all cases the largest effect was on dGTP, the preferred substrate of SAMHD1 | Homo sapiens |