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Literature summary for 3.1.4.53 extracted from

  • Nunes, A.R.; Batuca, J.R.; Monteiro, E.C.
    Acute hypoxia modifies cAMP levels induced by inhibitors of phosphodiesterase-4 in rat carotid bodies, carotid arteries and superior cervical ganglia (2010), Br. J. Pharmacol., 159, 353-361.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
erythro-9-(2-hydroxy-3-nonyl)adenine a PDE2 selective inhibitor Rattus norvegicus
isobutylmethylxanthine a non-specific PDE inhibitor Rattus norvegicus
rolipram Ro 20-1724, a PDE4 selective inhibitor Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
carotid artery PDE4 Rattus norvegicus
-
carotid body PDE4 Rattus norvegicus
-
superior cervical ganglion PDE4 and PDE2 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
PDE2
-
 Rattus norvegicus
PDE4
-
 Rattus norvegicus
phosphodiesterase-4
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction effects of acute hypoxia on cAMP accumulation induced by PDE inhibitors in oxygen-specific chemosensors, the carotid bodies and in non-chemosensitive CB-related structures: carotid arteries and superior cervical ganglia, overview. Acute hypoxia enhances the effects of IBMX and PDE4 inhibitors on cAMP accumulation in carotid arteries and bodies, while in superior cervical ganglia In SCG, acute hypoxia reduces cAMP accumulation induced by all the four PDE inhibitors Rattus norvegicus