Inhibitors | Comment | Organism | Structure |
---|---|---|---|
8-methoxymethyl-isobutylmethylxanthine | inhibits activated PDE1 and PDE2 isoforms as well as PDE4 and PDE5 | Bos taurus | |
dioclein | dioclein is at least 11times more potent in inhibiting calmodulin-activated PDE1 than other PDE types. Among PDE1-PDE5, dioclein is at least 19fold more selective for the activated PDE1 isoform compared to PDE3 | Bos taurus | |
rolipram | - |
Bos taurus | |
vinpocetine | inhibitor of activated isoform PDE4 | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
anion exchange chromatography | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aortic smooth muscle | isoform PDE4 | Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | - |
Bos taurus | 5'-AMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE4 | isoform | Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0007 | - |
isoform PDE4, pH and temperature not specified in the publication | Bos taurus | rolipram | |
0.0168 | - |
isoform PDE4, pH and temperature not specified in the publication | Bos taurus | dioclein | |
0.131 | - |
isoform PDE4, pH and temperature not specified in the publication | Bos taurus | vinpocetine |