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Literature summary for 3.1.4.53 extracted from

  • Soderling, S.H.; Bayuga, S.J.; Beavo, J.A.
    Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase (1998), Proc. Natl. Acad. Sci. USA, 95, 8991-8996.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.53

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
dipyridamole
-
 Mus musculus
papaverine
-
 Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00015
-
 adenosine 3',5'-cyclic phosphate
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus O88502
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order Mus musculus
-
embryo highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order Mus musculus
-
eye highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order Mus musculus
-
heart highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order Mus musculus
-
kidney highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order Mus musculus
-
liver highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order Mus musculus
-
ovary highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order Mus musculus
-
skeletal muscle highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order Mus musculus
-
testis highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order. In testis PDE8 is expressed in the seminiferous epithelium in a stage-specific manner Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine 3',5'-cyclic phosphate + H2O PDE8 is specific for the hydrolysis of cAMP Mus musculus adenosine 5'-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
cAMP-specific cyclic nucleotide phosphodiesterase
-
 Mus musculus
cAMP-specific PDE
-
 Mus musculus
PDE8
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0045
-
-
 Mus musculus dipyridamole
0.174
-
-
 Mus musculus papaverine