Literature summary for 3.1.4.52 extracted from

Bassis, C.M.; Visick, K.L.
The cyclic-di-GMP phosphodiesterase BinA negatively regulates cellulose-containing biofilms in Vibrio fischeri (2010), J. Bacteriol., 192, 1269-1278.

Search for more literature for 3.1.4.52

Cloned(Commentary)

Cloned (Comment)	Organism
overexpression of BinA in Vibrio fischeri enhancing motility. Expression of wild-type and mutant enzymes in Escherichia coli	Aliivibrio fischeri

Protein Variants

Protein Variants	Comment	Organism
additional information	disruption or deletion of binA increased biofilm formation in culture and leads to increased cellulose production. The phenotypes of the DELTAbinA mutant strain can be disrupted by insertions in genes in the bacterial cellulose biosynthesis cluster	Aliivibrio fischeri

Organism

Organism	UniProt	Comment	Textmining
Aliivibrio fischeri	-	gene binA	-

Synonyms

Synonyms	Comment	Organism
BinA	-	Aliivibrio fischeri
cyclic-di-GMP phosphodiesterase	-	Aliivibrio fischeri

Expression

Organism	Comment	Expression
Aliivibrio fischeri	overexpression of the syp regulator sypG induces binA expression	up

General Information

General Information	Comment	Organism
malfunction	overexpression of BinA enhances motility. Disruption or deletion of binA increased biofilm formation in culture and leads to increased cellulose production. The phenotypes of the DELTAbinA mutant strain can be disrupted by insertions in genes in the bacterial cellulose biosynthesis cluster, suggesting that cellulose production is negatively regulated by Bin A	Aliivibrio fischeri
physiological function	a key regulator of biofilm formation in bacteria is the intracellular signaling molecule cyclic diguanylate. Cyclic-di-GMP phosphodiesterase BinA negatively regulates cellulose-containing biofilms in Vibrio fischeri, BinA functions as a phosphodiesterase, its activity depends on the EAL domain, and cyclic di-GMP activates cellulose biosynthesis	Aliivibrio fischeri

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Release 2023.1 (January 2023)