Literature summary for 3.1.4.37 extracted from

Ma, H.; Zhao, X.L.; Wang, X.Y.; Xie, X.W.; Han, J.C.; Guan, W.L.; Wang, Q.; Zhu, L.; Pan, X.B.; Wei, L.
2',3'-cyclic nucleotide 3'-phosphodiesterases inhibit hepatitis B virus replication (2013), PLoS ONE, 8, e80769.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	isozyme CNP1	Homo sapiens	5829	-
mitochondrion	the N-terminus ofisozyme CNP2 serves as a mitochondrial targeting signal and translocates it to the mitochondrion	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09543	isoforms CNP1 and CNP2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293T cell	-	Homo sapiens	-
Hep-G2 cell	-	Homo sapiens	-
hepatoma cell	quantitative isozymes expression analysis in hepatoma cell lines	Homo sapiens	-
Huh-7 cell	-	Homo sapiens	-
liver	the enzyme is expressed in liver tissues with hepatitis B virus infection	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
2',3'-cyclic nucleotide 3'-phosphodiesterase	-	Homo sapiens
CNP	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	knockdown of the enzyme expression moderately improves hepatitis B viral production in the HepG2.2.15 cells treated with IFN-alpha	Homo sapiens
physiological function	the enzyme might be a mediator of interferon-induced response against hepatitis B virus. Isozymes CNP1 and CNP2 potently inhibit hepatitis B virus production by blocking viral proteins synthesis and reducing viral RNAs, respectively. Inhibition by isozymes CNP1 and CNP2 appear to have distinct mechanism. In chronic hepatitis B patients, the enzyme is expressed in most of hepatitis B virus -infected hepatocytes of liver specimens. Because the enzyme targets the poly(A) of mRNA, it exhibited a nonspecific effect on protein synthesis	Homo sapiens

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Release 2023.1 (January 2023)