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Literature summary for 3.1.4.37 extracted from

  • Yang, L.; Kan, E.M.; Lu, J.; Wu, C.; Ling, E.A.
    Expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) and its roles in activated microglia in vivo and in vitro (2014), J. Neuroinflammation, 11, 148.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.37

Protein Variants

Protein Variants Comment Organism
additional information enzyme knockdown by siRNA knockdown of CNPase in BV-2 cells Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Rattus norvegicus Sprague-Dawley
-
-
-
Rattus norvegicus Wistar
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amoeboid microglial cell
-
 Rattus norvegicus
-
brain amoeboid microglial cells in the postnatal rat brain Rattus norvegicus
-
BV-2 cell
-
 Mus musculus
-
microglia
-
 Mus musculus
-
microglia
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
2',3'-cyclic nucleotide 3'-phosphodiesterase
-
 Mus musculus
2',3'-cyclic nucleotide 3'-phosphodiesterase
-
 Rattus norvegicus
CNPase
-
 Mus musculus
CNPase
-
 Rattus norvegicus

Expression

Organism Comment Expression
Mus musculus markedly enhanced enzyme expression, CNPase protein and mRNA expression, in microglia after activation by lipopolysaccharide treatment up
Rattus norvegicus markedly enhanced enzyme expression, CNPase protein and mRNA expression, in microglia after activation by lipopolysaccharide treatment up

General Information

General Information Comment Organism
malfunction inducible nitric oxide synthase, IL-1beta, TNF-alpha, reactive oxygen species and nitric oxide are significantly upregulated in activated BV-2 cells with CNPase enzyme knockdown. siRNA knockdown of the enzyme increases microglia migration, on the other hand, microglial cells appear to be arrested at G1 phase Mus musculus
physiological function the enzyme encoding gene may play an important role as a putative anti-inflammatory gene both in normal and injured brain Mus musculus
physiological function the enzyme encoding gene may play an important role as a putative anti-inflammatory gene both in normal and injured brain Rattus norvegicus