Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial membrane | - |
Rattus norvegicus | 31966 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | Ca2+-stimulated and permeability transition pore-associated enzyme phosphorylation | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
46000 | - |
x * 46000, phosphorylated mitochondrial enzyme, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2',3'-cyclic AMP + H2O | Rattus norvegicus | - |
2'-AMP | - |
? | |
nucleoside 2',3'-cyclic phosphate + H2O | Rattus norvegicus | - |
nucleoside 2'-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Ca2+-stimulated and permeability transition pore-associated enzyme phosphorylation on Ser and Thr residues. Permeability transition pore inducer Atr is able to stimulate the ATP incorporation into 46 kDa enzyme in the presence of threshold Ca2+, whereas CsA suppresses significantly phosphorylation of the enzyme | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2',3'-cyclic AMP + H2O | - |
Rattus norvegicus | 2'-AMP | - |
? | |
nucleoside 2',3'-cyclic phosphate + H2O | - |
Rattus norvegicus | nucleoside 2'-phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 46000, phosphorylated mitochondrial enzyme, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
2',3'-cyclic nucleotide 3'-phosphodiesterase | - |
Rattus norvegicus |
CNPase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | Ca2+-stimulated and permeability transition pore-associated enzyme phosphorylation might be an important stage of permeability transition pore regulation in mitochondria, revealing an additional function of CNPase outside of myelin structure | Rattus norvegicus |