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Literature summary for 3.1.4.37 extracted from
- 2', 3'-cyclic nucleotide 3'-phosphodiesterase is expressed in dissociated rat cerebellar cells and included in the postsynaptic density fraction (2003), Mol. Cells, 16, 128-135.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 46000 | - |
x * 46000, CNP1, x * 48000, CNP2, SDS-PAGE | Rattus norvegicus |
| 48000 | - |
x * 46000, CNP1, x * 48000, CNP2, SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | myelin-specific protein, synthesized by oligodendrocytes, more abundant in the myelin of the CNS than in that of the peripheral nervous system, CNP is regulated by several protein kinases and may have a role in morphological changes of the cells by modulating the cytoskeleton | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Sprague-Dawley rats, adult, 2 isoforms: CNP1 and CNP2, produced by ribosome initiation at different AUG codons | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | both isoforms CNP1 and CNP2 are tyrosine-phosphorylated to a basal extend | Rattus norvegicus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | there is little CNP2 in the forebrain postsynaptic density fraction, CNP1 is the major isoform in the neural and non-neural rat tissues, with the exception of myelinating cells in the adult brain, in which both isoforms are highly expressed, CNP2 is barely detectable in embryonic brain | Rattus norvegicus | - |
| cerebellar Purkinje cell | cerebellar, both isoforms CNP1 and CNP2 | Rattus norvegicus | - |
| cerebellum | cerebellar postsynaptic density fraction, both isoforms CNP1 and CNP2 are expressed in cerian populations of cerebellar cells, in oligodendrocytes, Purkinje cells and unidentified PSD95-positive cells, not in granule cells | Rattus norvegicus | - |
| additional information | CNP2 is barely detectable in testis and thymus | Rattus norvegicus | - |
| oligodendrocyte | cerebellar, both isoforms CNP1 and CNP2 | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | myelin-specific protein, synthesized by oligodendrocytes, more abundant in the myelin of the CNS than in that of the peripheral nervous system, CNP is regulated by several protein kinases and may have a role in morphological changes of the cells by modulating the cytoskeleton | Rattus norvegicus | ? | - |
? | |
| nucleoside 2',3'-cyclic phosphate + H2O | - |
Rattus norvegicus | nucleoside 2'-phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 46000, CNP1, x * 48000, CNP2, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CNP1 | - |
Rattus norvegicus |
| CNP2 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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