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Literature summary for 3.1.4.37 extracted from

  • Barradas, P.C.; Ferraz, A.S.; Ferreira, A.A.; Daumas, R.P.; Moura, E.G.
    2'3'Cyclic nucleotide 3'phosphodiesterase immunohistochemistry shows an impairment on myelin compaction in hypothyroid rats (2000), Int. J. Dev. Neurosci., 18, 887-892.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information hypothyroidism impairs transiently the CNPase gene expression, rats receiving methimazol during gestation or postnatally show a delay in CNPase expression followed by a decrease in the number of CNPase immunoreactive fibers Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus early oligodendroglial marker, CNPase links myelin related proteins to the cytoskeleton also interacting with membrane lipids during extension and wrapping of the oligodendroglial process around the axon, in mature myelinated fiber the CNPase is absent from compact myelin sheath, being located only in the inner and outer loops and in paranodal loops ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Wistar rats, from post-natal days 5 to 90, hypothyroid and controls
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Source Tissue

Source Tissue Comment Organism Textmining
brain CNPase expression pattern of brain tissues in hypothyroid and control rats from post-natal days 5 to 90, hypothyroidism impairs transiently the CNPase gene expression, effect on oligodendrocyte differentiation and myelination Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information early oligodendroglial marker, CNPase links myelin related proteins to the cytoskeleton also interacting with membrane lipids during extension and wrapping of the oligodendroglial process around the axon, in mature myelinated fiber the CNPase is absent from compact myelin sheath, being located only in the inner and outer loops and in paranodal loops Rattus norvegicus ?
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nucleoside 2',3'-cyclic phosphate + H2O
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Rattus norvegicus nucleoside 2'-phosphate
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