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Literature summary for 3.1.4.35 extracted from

  • Laties, A.M.
    Vision disorders and phosphodiesterase type 5 inhibitors: a review of the evidence to date (2009), Drug Saf., 32, 1-18.
    View publication on PubMed
Search for more literature for 3.1.4.35

Application

Application Comment Organism
medicine oral PDE-5 inhibitors are the current first-line treatment for erectile dysfunction Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
sildenafil
-
 Homo sapiens
tadalafil
-
 Homo sapiens
vardenafil
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3',5'-cGMP + H2O Homo sapiens
-
 5'-GMP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cGMP + H2O
-
 Homo sapiens 5'-GMP
-
 ?

Synonyms

Synonyms Comment Organism
PDE-5
-
 Homo sapiens
phosphodiesterase type 5
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction inhibition of PDE-5 slows cGMP degradation, leading to increased levels of cGMP and greater blood flow through the corpus cavernosum when nitric oxide is released during sexual stimulation, PDE-5 inhibitors have little effect on corpus cavernosum blood flow Homo sapiens