Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2-dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride | specific inhibitor of PDE5 | Homo sapiens | |
dipyridamole | PDE5 is specifically inhibited by dipyridamole | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O76074 | PDE5A | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
umbilical artery smooth muscle | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cGMP + H2O | PDE5 hydrolyses selectively 3',5'-cGMP with high affinity | Homo sapiens | 5'-GMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE5 | key enzyme involved in the regulation of the smooth muscle relaxation associated to cGMP | Homo sapiens |
PDE5A | isoform | Homo sapiens |