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Literature summary for 3.1.4.35 extracted from

  • Almeida, C.B.; Traina, F.; Lanaro, C.; Canalli, A.A.; Saad, S.T.; Costa, F.F.; Conran, N.
    High expression of the cGMP-specific phosphodiesterase, PDE9A, in sickle cell disease (SCD) and the effects of its inhibition in erythroid cells and SCD neutrophils (2008), Br. J. Haematol., 142, 836-844.
    View publication on PubMed
Search for more literature for 3.1.4.35

Inhibitors

Inhibitors Comment Organism Structure
BAY 73-6691 specific PDE9A inhibitor Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
72000
-
 PDE9, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
colon low gene expression Homo sapiens
-
erythroid cell
-
 Homo sapiens
-
heart low gene expression Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
kidney low gene expression Homo sapiens
-
liver low gene expression Homo sapiens
-
lung low gene expression Homo sapiens
-
additional information not detected in lymph node, mammary gland, ovary, skeletal muscle, testicle, and uterus Homo sapiens
-
neutrophil PFE9A gene expression is higher in neutrophils from sickle cell disease individuals compared to control cells Homo sapiens
-
reticulocyte PFE9A gene expression is higher in reticulocytes from sickle cell disease individuals compared to control cells Homo sapiens
-
skin low gene expression Homo sapiens
-
spleen low gene expression Homo sapiens
-
T-98G cell low gene expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cGMP + H2O
-
 Homo sapiens 5'-GMP
-
 ?

Synonyms

Synonyms Comment Organism
cGMP-specific phosphodiesterase
-
 Homo sapiens
PDE9A
-
 Homo sapiens