Literature summary for 3.1.4.35 extracted from

Grant, J.E.; Guo, L.W.; Vestling, M.M.; Martemyanov, K.A.; Arshavsky, V.Y.; Ruoho, A.E.
The N terminus of GTP gamma S-activated transducin alpha-subunit interacts with the C terminus of the cGMP phosphodiesterase gamma-subunit (2006), J. Biol. Chem., 281, 6194-6202.

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Activating Compound

Activating Compound	Comment	Organism	Structure
alpha-subunit of transducin	activation of isoform PDE6 by binding to the inhibitory gamma-subunit	Bos taurus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	of rod outer segment	Bos taurus	16020	-

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	isoform PDE6	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
retinal rod	outer segment membrane	Bos taurus	-

Subunits

Subunits	Comment	Organism
More	alpha-subunit of transducin interacts with the inhibitory gamma subunit of PDE6 thereby activating the enzyme. Interaction requires activated alpha-subunit of transducin and involves the C-terminus of PDE6 gamma-subunit, particularly residue 73	Bos taurus

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Release 2023.1 (January 2023)