Literature summary for 3.1.4.35 extracted from

Huai, Q.; Liu, Y.; Francis, S.H.; Corbin, J.D.; Ke, H.
Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity (2004), J. Biol. Chem., 279, 13095-13101.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop method, PDE5A1 in complex with the nonselective inhibitor 3-isobutyl-1-methylxanthine	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
3-isobutyl-1-methylxanthine	the inhibitor binds to a subpocket that comprises key residues Val782, Ph2786, Gln817 and Phe820 of PDE5A1. This subpocket may be a common site for binding nonselective inhibitors	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O76074	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Synonyms

Synonyms	Comment	Organism
cGMP-specific PDE5A1	-	Homo sapiens
PDE5A1	-	Homo sapiens
phosphodiesterase 5	-	Homo sapiens

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Release 2023.1 (January 2023)