Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-isobutyl-1-methylxanthine | 0.0058 mM, 50% inhibition | Canis lupus familiaris | |
3-isobutyl-1-methylxanthine | 0.0058 mM, 50% inhibition | Homo sapiens | |
3-isobutyl-1-methylxanthine | 0.0054 mM, 50% inhibition | Oryctolagus cuniculus | |
dipyridamole | 0.0013 mM, 50% inhibition | Canis lupus familiaris | |
dipyridamole | 0.00075 mM, 50% inhibition | Homo sapiens | |
dipyridamole | 0.0012 mM, 50% inhibition | Oryctolagus cuniculus | |
sildenafil | 0.0000017 mM, 50% inhibition | Canis lupus familiaris | |
sildenafil | 0.0000036 mM, 50% inhibition | Homo sapiens | |
sildenafil | 0.000003 mM, 50% inhibition | Oryctolagus cuniculus | |
zaprinast | 0.0002 mM, 50% inhibition | Canis lupus familiaris | |
zaprinast | 0.0003 mM, 50% inhibition | Homo sapiens | |
zaprinast | 0.000053 mM, 50% inhibition | Oryctolagus cuniculus | |
Zn2+ | complete inhibition above 0.1 mM | Canis lupus familiaris | |
Zn2+ | strong inhibition above 0.01 mM, almost complete inhibition at 0.1 mM | Homo sapiens | |
Zn2+ | strong inhibition above 0.01 mM, complete inhibition at 0.1 mM | Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0008 | - |
cGMP | 30°C, pH 7.4 | Homo sapiens | |
0.001 | - |
cGMP | 30°C, pH 7.4, platelet PDE5 | Homo sapiens | |
0.002 | - |
cGMP | 30°, pH 7.4 | Canis lupus familiaris | |
0.0023 | - |
cGMP | 30°C, pH 7.4 | Oryctolagus cuniculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required for activity, approx. 1.5fold activation at 1 mM | Oryctolagus cuniculus | |
Mg2+ | required for activity, approx. 2.5fold activation at 1 mM | Homo sapiens | |
Mg2+ | required for activity, approx. 2fold activation at 1 mM | Canis lupus familiaris | |
Zn2+ | approx. 2.5 fold activation at 0.01 mM, strong inhibition above | Homo sapiens | |
Zn2+ | slight activation at 0.01 mM, strong inhibition above | Canis lupus familiaris |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanosine 3',5'-cyclic phosphate + H2O | Homo sapiens | - |
guanosine 5'-phosphate | - |
? | |
guanosine 3',5'-cyclic phosphate + H2O | Oryctolagus cuniculus | - |
guanosine 5'-phosphate | - |
? | |
guanosine 3',5'-cyclic phosphate + H2O | Canis lupus familiaris | - |
guanosine 5'-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Mono Q, partially purified | Homo sapiens |
Mono Q, partially purified | Oryctolagus cuniculus |
Mono Q, partially purified | Canis lupus familiaris |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
corpus cavernosum | - |
Homo sapiens | - |
corpus cavernosum | - |
Canis lupus familiaris | - |
platelet | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanosine 3',5'-cyclic phosphate + H2O | - |
Homo sapiens | guanosine 5'-phosphate | - |
? | |
guanosine 3',5'-cyclic phosphate + H2O | - |
Oryctolagus cuniculus | guanosine 5'-phosphate | - |
? | |
guanosine 3',5'-cyclic phosphate + H2O | - |
Canis lupus familiaris | guanosine 5'-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE5 | - |
Homo sapiens |
PDE5 | - |
Oryctolagus cuniculus |
PDE5 | - |
Canis lupus familiaris |
type 5 phosphodiesterase | - |
Homo sapiens |
type 5 phosphodiesterase | - |
Oryctolagus cuniculus |
type 5 phosphodiesterase | - |
Canis lupus familiaris |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Homo sapiens |
7.5 | - |
- |
Oryctolagus cuniculus |
7.5 | - |
- |
Canis lupus familiaris |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 8.5 | almost no activity at pH 6.0 and 8.5, respectively | Homo sapiens |
6.5 | 8.5 | almost no activity at pH 6.5 and pH 8.5, respectively | Canis lupus familiaris |
6.5 | 8.5 | very low activity at pH 6.5 and 8.5, respectively | Oryctolagus cuniculus |