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Literature summary for 3.1.4.35 extracted from
- The cGMP-binding, cGMP-specific phosphodiesterase (PDE5): intestinal cell expression, regulation and role in fluid secretion (2004), Cell. Signal., 16, 681-692.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cGMP | activation by suggested binding to PDE5 GAF domain | Homo sapiens |  |
| Escherichia coli stable toxin | possibly due to an increase in cGMP resulting from stable toxin treatment | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| splice variants PDE5A1 and PDE5A2 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| sildenafil citrate | inhibition of PDE5 activity in the intestine, which might occur during sildenafil citrate ingestion, could result in a transitory diarrhoe | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 105000 | - |
2 * 105000, immunoblot | Homo sapiens |
| 200000 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanosine 3',5'-cyclic phosphate + H2O | Homo sapiens | - |
guanosine 5'-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O76074 | splice variants PDE5A1 and PDE5A2 | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | phosphorylation presumably by protein kinase A or protein kinase G | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cecum | - |
Homo sapiens | - |
| colon | - |
Homo sapiens | - |
| duodenum | - |
Homo sapiens | - |
| ileum | - |
Homo sapiens | - |
| jejunum | - |
Homo sapiens | - |
| stomach | - |
Homo sapiens | - |
| T-84 cell | colonic T84 cells | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanosine 3',5'-cyclic phosphate + H2O | - |
Homo sapiens | guanosine 5'-phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 105000, immunoblot | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cGMP-binding cGMP-specific phosphodiesterase | - |
Homo sapiens |
| PDE5 | - |
Homo sapiens |
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