Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.35 extracted from

  • Liu, L.; Underwood, T.; Li, H.; Pamukcu, R.; Thompson, W.J.
    Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase (2002), Cell. Signal., 14, 45-51.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cloning of cGMP-binding domain and expression as GST-fusion protein in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CP461
-
Homo sapiens
E4021
-
Homo sapiens
exisulind
-
Homo sapiens
zaprinast
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
guanosine 3',5'-cyclic phosphate + H2O Homo sapiens
-
guanosine 5'-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HT-29 cell colon cancer cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
guanosine 3',5'-cyclic phosphate + H2O
-
Homo sapiens guanosine 5'-phosphate
-
?

Subunits

Subunits Comment Organism
More two homologous noncatalytic cyclic GMP-binding sites located in the N-terminal half of PDE5 Homo sapiens

Synonyms

Synonyms Comment Organism
cGMP-binding cGMP specific phosphodiesterase
-
Homo sapiens
PDE5
-
Homo sapiens