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Literature summary for 3.1.4.35 extracted from
- Expression of three isoforms of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in human penile cavernosum (2000), Biochem. Biophys. Res. Commun., 268, 628-635.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of PDE isoenzymes PDEA1, PDEA2 and PDEA3 in COS-7 cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| sildenafil | - |
Homo sapiens |  |
| zaprinast | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0058 | - |
cGMP | 37°C, pH 7.4, recombinant isoenzyme PDE5A2 | Homo sapiens | |
| 0.006 | - |
cGMP | 37°C, pH 7.4, recombinant isoenzyme PDE5A3 | Homo sapiens | |
| 0.0062 | - |
cGMP | 37°C, pH 7.4, recombinant isoenzyme PDE5A1 | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanosine 3',5'-cyclic phosphate + H2O | Homo sapiens | - |
guanosine 5'-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isoenzymes PDE5A1, PDE5A2 and PDE5A3 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bladder | - |
Homo sapiens | - |
| corpus cavernosum | - |
Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| prostate | - |
Homo sapiens | - |
| smooth muscle | smooth muscle specific expression of PDE5A3 | Homo sapiens | - |
| urethra | - |
Homo sapiens | - |
| uterus | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanosine 3',5'-cyclic phosphate + H2O | - |
Homo sapiens | guanosine 5'-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cGMP-binding cGMP-specific phosphodiesterase | - |
Homo sapiens |
| PDE5 | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000013 | - |
sildenafil | 37°C, pH 7.4, recombinant isoenzyme PDE5A3 | Homo sapiens | |
| 0.000014 | - |
sildenafil | 37°C, pH 7.4, recombinant isoenzyme PDE5A2 | Homo sapiens | |
| 0.000028 | - |
sildenafil | 37°C, pH 7.4, recombinant isoenzyme PDE5A1 | Homo sapiens | |
| 0.0013 | - |
zaprinast | 37°C, pH 7.4, recombinant isoenzyme PDE5A2 | Homo sapiens | |
| 0.0016 | - |
zaprinast | 37°C, pH 7.4, recombinant isoenzyme PDE5A3 | Homo sapiens | |
| 0.0032 | - |
zaprinast | 37°C, pH 7.4, recombinant isoenzyme PDE5A1 | Homo sapiens | |
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