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Literature summary for 3.1.4.3 extracted from

  • Shao, J.; Sun, C.; Su, L.; Zhao, J.; Zhang, S.; Miao, J.
    Phosphatidylcholine-specific phospholipase C/heat shock protein 70 (Hsp70)/transcription factor B-cell translocation gene 2 signaling in rat bone marrow stromal cell differentiation to cholinergic neuron-like cells (2012), Int. J. Biochem. Cell Biol., 44, 2253-2260.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
tricyclodecan-9-yl-xanthogenate i.e. D609, specific inhibitor, does not inhibit sphingomyelin synthase Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + H2O Rattus norvegicus
-
 1,2-sn-diacylglycerol + phosphocholine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow stromal cell cholinergic neuron-like cells Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + H2O
-
 Rattus norvegicus 1,2-sn-diacylglycerol + phosphocholine
-
 ?

Synonyms

Synonyms Comment Organism
PC-PLC
-
 Rattus norvegicus
phosphatidylcholine-specific phospholipase C
-
 Rattus norvegicus

General Information

General Information Comment Organism
evolution the enzyme is a the member of phospholipase C family Rattus norvegicus
physiological function the enzyme is involved in PC-PLC-medicated neuronal differentiation of bone marrow stromal cells, and heat shock protein 70 is the pivotal factor by blocking phospholipase C inhibitor D609-induced increase of transcription factor B-cell translocation gene 2 expression and cholinergic neuronal differentiation of bone marrow stromal cells, overview Rattus norvegicus