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Literature summary for 3.1.4.2 extracted from
- Rat kidney glycerylphosphorylcholine diesterase (1968), Biochim. Biophys. Acta, 164, 195-204.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| choline | - |
Rattus sp. |  |
| citrate | 24% inhibition at 6 mM | Rattus sp. | |
| EDTA | - |
Rattus sp. | |
| ethanolamine | - |
Rattus sp. | |
| N,N-dimethylethanolamine | - |
Rattus sp. | |
| N-Methylethanolamine | - |
Rattus sp. | |
| phosphate | 71% inhibition at 6 mM | Rattus sp. | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.2 | - |
sn-glycero 3-phosphorylcholine | - |
Rattus sp. | |
| 2.5 | - |
sn-glycero 3-phosphorylethanolamine | - |
Rattus sp. | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus sp. | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sn-glycero 3-phosphorylcholine + H2O | Rattus sp. | cellular phosphatidylcholine catabolic pathway | ? | - |
? | |
| sn-glycero 3-phosphorylethanolamine + H2O | Rattus sp. | cellular phosphatidyethanolamine catabolic pathway | ? | - |
? | |
Organic Solvent Stability
| Organic Solvent | Comment | Organism |
|---|---|---|
| Acetone | 90% v/v, 50% loss of activity | Rattus sp. |
| Ethanol | 90% v/v, 80% loss of activity | Rattus sp. |
| isopropanol | 90% v/v, 24% loss of activity | Rattus sp. |
| Methanol | 70% v/v, complete denaturation | Rattus sp. |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus sp. | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial, 17-fold purification | Rattus sp. |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus sp. | - |
| lung | - |
Rattus sp. | - |
| spleen | - |
Rattus sp. | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.195 | - |
freezing and thawing increases specific activity | Rattus sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sn-glycero 3-phosphorylcholine + H2O | - |
Rattus sp. | sn-glycerol 3-phosphate + choline | - |
? | |
| sn-glycero 3-phosphorylcholine + H2O | cellular phosphatidylcholine catabolic pathway | Rattus sp. | ? | - |
? | |
| sn-glycero 3-phosphorylethanolamine + H2O | - |
Rattus sp. | sn-glycerol 3-phosphate + ethanolamine | - |
? | |
| sn-glycero 3-phosphorylethanolamine + H2O | cellular phosphatidyethanolamine catabolic pathway | Rattus sp. | ? | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
10% inactivation after 5 min | Rattus sp. |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9.3 | - |
- |
Rattus sp. |
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Release 2023.1 (January 2023)
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