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Literature summary for 3.1.4.17 extracted from

  • Weninger, S.; Van Craenenbroeck, K.; Cameron, R.T.; Vandeput, F.; Movsesian, M.A.; Baillie, G.S.; Lefebvre, R.A.
    Phosphodiesterase 4 interacts with the 5-HT4(b) receptor to regulate cAMP signaling (2014), Cell. Signal., 26, 2573-2582.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Synonyms

Synonyms Comment Organism
PDE3A
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Homo sapiens

General Information

General Information Comment Organism
physiological function constitutive signaling of the overexpressed HA-tagged 5-hydroxytryptamine4(b) receptor in HEK293 cells is regulated predominantly by cAMP-specific phosphodiesterase PDE4,with a secondary role for dual specific phosphodiesterase PDE3 that is unmasked in the presence of PDE4 inhibition. Overexpressed PDE4D3 and PDE3A1, and to a smaller extent PDE4D5 co-immunoprecipitate constitutively with the 5-hydroxytryptamine4(b) receptor Homo sapiens