Application | Comment | Organism |
---|---|---|
medicine | genetic disruption or pharmacological inhibition of PDE10A reverses behavioral abnormalities associated with subcortical hyperdopaminergia | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[[4-[4-pyridin-4-yl-1-(2,2, 2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline succinic acid | selective PDE10A inhibitor, inhibition of striatal PDE10A activity increases the responsiveness of medium-sized spiny projection neurons to depolarising stimuli | Rattus norvegicus | |
papaverine | selective PDE10A inhibitor | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
corpus striatum | dorsal striatum | Rattus norvegicus | - |
neuron | PDE10A is highly expressed in striatal medium-sized spiny projection neurons | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | - |
Rattus norvegicus | 5'-AMP | - |
? | |
3',5'-cGMP + H2O | - |
Rattus norvegicus | 5'-GMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cyclic nucleotide phosphodiesterase 10A | - |
Rattus norvegicus |
PDE10A | - |
Rattus norvegicus |