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Literature summary for 3.1.4.17 extracted from

  • Santos-Silva, A.J.; Cairrao, E.; Morgado, M.; Alvarez, E.; Verde, I.
    PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries (2008), Eur. J. Pharmacol., 582, 102-109.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cGMP PDE2 is stimulated by cGMP Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-isobutyl-1-methylxanthine broad-spectrum PDE inhibitor; broad-spectrum PDE inhibitor; broad-spectrum PDE inhibitor Homo sapiens
8-methoxymethyl-3-isobutyl-1-methylxanthine 0.02 mM selectively inhibits PDE1; 0.02 mM selectively inhibits PDE1 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+ activates Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O00408 PDE2A
-
Homo sapiens P54750 PDE1A
-
Homo sapiens Q01064 PDE1B
-

Source Tissue

Source Tissue Comment Organism Textmining
umbilical artery smooth muscle
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
Homo sapiens 5'-AMP
-
?
3',5'-cGMP + H2O
-
Homo sapiens 5'-GMP
-
?

Synonyms

Synonyms Comment Organism
PDE1
-
Homo sapiens
PDE1A isoform Homo sapiens
PDE1B isoform Homo sapiens
PDE2
-
Homo sapiens
PDE2A isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
Calmodulin
-
Homo sapiens