Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cGMP | PDE2 is stimulated by cGMP | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-isobutyl-1-methylxanthine | broad-spectrum PDE inhibitor; broad-spectrum PDE inhibitor; broad-spectrum PDE inhibitor | Homo sapiens | |
8-methoxymethyl-3-isobutyl-1-methylxanthine | 0.02 mM selectively inhibits PDE1; 0.02 mM selectively inhibits PDE1 | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | Ca2+ activates | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00408 | PDE2A | - |
Homo sapiens | P54750 | PDE1A | - |
Homo sapiens | Q01064 | PDE1B | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
umbilical artery smooth muscle | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | - |
Homo sapiens | 5'-AMP | - |
? | |
3',5'-cGMP + H2O | - |
Homo sapiens | 5'-GMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE1 | - |
Homo sapiens |
PDE1A | isoform | Homo sapiens |
PDE1B | isoform | Homo sapiens |
PDE2 | - |
Homo sapiens |
PDE2A | isoform | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | - |
Homo sapiens |