Literature summary for 3.1.4.17 extracted from

Hepp, R.; Tricoire, L.; Hu, E.; Gervasi, N.; Paupardin-Tritsch, D.; Lambolez, B.; Vincent, P.
Phosphodiesterase type 2 and the homeostasis of cyclic GMP in living thalamic neurons (2007), J. Neurochem., 102, 1875-1886.

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Inhibitors

Inhibitors	Comment	Organism	Structure
BAY60-7550	inhibition of isoform PDE2, results in increase in basal cGMP levels after application to thalamic neurons	Mus musculus
erythro-9-(2-hydroxy-3-nonyl)adenine	inhibition of isoform PDE2, results in increase in basal cGMP levels after application to thalamic neurons	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	isoform PDE2 regulates the basal cGMP concentration in thalamic neuron	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q01065	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
neuron	living thalamic neurons, expression of enzyme isoforms PDE1, PDE2, PDE9, and PDE10	Mus musculus	-
thalamus	living thalamic neurons, expression of enzyme isoforms PDE1, PDE2, PDE9, and PDE10	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	isoform PDE2 regulates the basal cGMP concentration in thalamic neuron	Mus musculus	?	-	?

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Release 2023.1 (January 2023)