Protein Variants | Comment | Organism |
---|---|---|
additional information | chimera of isoform PDE10 GAF-domain and cyanobacterial cyclase is stimulated 9fold by cAMP, whereas cGMP has only low activity. CAMP increases Vmax in a non-cooperative manner and does not influence the Km value. Mutation of the D residue within the invariant NKFDE motif of the GAF domain reduces intramolecular signaling considerably | Homo sapiens |
additional information | chimera of isoform PDE11 GAF-domain and cyanobacterial cyclase shows non-cooperative 4fold increase in Vmax. Mutation of the D residue within the invariant NKFDE motif of the GAF domain reduces intramolecular signaling considerably | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9HCR9 | isoform PDE11A4 | - |
Homo sapiens | Q9Y233 | isoform PDE10A1 | - |