Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(6aS,9aR)-3-benzyl-2-(biphenyl-4-ylmethyl)-5-methyl-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[2,1-b]purin-4(3H)-one | comparison of inhibitory effect on several recombinant human PDE isoforms. Effective PDE1 inhibitor in cellular context | Homo sapiens | |
3'-benzyl-2'-(biphenyl-4-ylmethyl)-5'-methyl-3'H-spiro[cyclopentane-1,7'-imidazo[2,1-b]purin]-4'(5'H)-one | comparison of inhibitory effect on several recombinant human PDE isoforms. Effective PDE1 inhibitor in cellular context | Homo sapiens | |
3-isobutyl-8-(methoxymethyl)-1-methyl-3,9-dihydro-1H-purine-2,6-dione | i.e. 8MM-IBMX, comparison of inhibitory effect on several recombinant human PDE isoforms | Homo sapiens | |
5-methyl-2-[4-(trifluoromethyl)benzyl]-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[2,1-b]purin-4(1H)-one | i.e. SCH51866, comparison of inhibitory effect on several recombinant human PDE isoforms. Effective PDE1 inhibitor in cellular context | Homo sapiens | |
vinpocetine | comparison of inhibitory effect on several recombinant human PDE isoforms | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0013 | - |
cGMP | isoform PDE1C, pH 7.4 | Homo sapiens | |
0.0017 | - |
cAMP | isoform PDE1C, pH 7.4 | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
72000 | - |
x * 72000, splice variant PDE1C1, x * 75000, splice variant PDE1C3 | Homo sapiens |
75000 | - |
x * 72000, splice variant PDE1C1, x * 75000, splice variant PDE1C3 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-172 cell | glioblastoma cell, expression of isoform PDE1C and lower levels of isoforms PDE2, PDE3, PDE4, and PDE5 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | - |
Homo sapiens | 5'-AMP | - |
? | |
3',5'-cGMP + H2O | - |
Homo sapiens | 5'-GMP | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 72000, splice variant PDE1C1, x * 75000, splice variant PDE1C3 | Homo sapiens |