Any feedback?
Literature summary for 3.1.4.17 extracted from
- Expression of PDE11A in normal and malignant human tissues (2005), J. Histochem. Cytochem., 53, 895-903.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione | IC50: 0.02654 mM, PDE4A4 | Homo sapiens |  |
| dipyridamole | IC50: 0.00034 mM, PDE4A4 | Homo sapiens | |
| sildenafil | IC50: 0.00315 mM, PDE4A4 | Homo sapiens | |
| zaprinast | IC50: 0.00816 mM, PDE4A4 | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme might be involved in multiple physiological processes in various organs via its ability to modulate intracellular cAMP and cGMP levels | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | epithelial and endothelial cells | Homo sapiens | - |
| colon | epithelial cells and macrophages | Homo sapiens | - |
| epidermis | - |
Homo sapiens | - |
| kidney | tubule epithelial cells | Homo sapiens | - |
| prostate gland | epithelial, endothelial and smooth muscle cells | Homo sapiens | - |
| testis | Leydig cells and spermatogenic cells | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme might be involved in multiple physiological processes in various organs via its ability to modulate intracellular cAMP and cGMP levels | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PDE11A | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00034 | - |
IC50: 0.00034 mM, PDE4A4 | Homo sapiens | dipyridamole | |
| 0.00315 | - |
IC50: 0.00315 mM, PDE4A4 | Homo sapiens | sildenafil | |
| 0.00816 | - |
IC50: 0.00816 mM, PDE4A4 | Homo sapiens | zaprinast | |
| 0.02654 | - |
IC50: 0.02654 mM, PDE4A4 | Homo sapiens | 3-isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
