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Literature summary for 3.1.4.17 extracted from

  • Grant, P.G.; Colman, R.W.
    Purification and characterization of a human platelet cyclic nucleotide phosphodiesterase (1984), Biochemistry, 23, 1801-1807.
    View publication on PubMed
Search for more literature for 3.1.4.17

Inhibitors

Inhibitors Comment Organism Structure
3-isobutyl-1-methylxanthine
-
 Homo sapiens
cAMP
-
 Homo sapiens
cGMP
-
 Homo sapiens
dipyridamole
-
 Homo sapiens
papaverine
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00002
-
 3',5'-cGMP
-
 Homo sapiens
0.00018
-
 3',5'-cAMP
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens
Mn2+ required Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
61000
-
 2 * 61000 Homo sapiens
140000
-
 gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
2500-3000fold Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
 Homo sapiens 5'-AMP
-
 ?
3',5'-cGMP + H2O
-
 Homo sapiens 5'-GMP
-
 ?
nucleoside 3',5'-cyclic phosphate + H2O
-
 Homo sapiens nucleoside 5'-phosphate
-
 ?

Subunits

Subunits Comment Organism
dimer SDS-PAGE Homo sapiens
dimer 2 * 61000 Homo sapiens