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Literature summary for 3.1.4.11 extracted from
- Phosphoinositide-specific phospholipase C beta1 signal transduction in the nucleus (2010), Methods Mol. Biol., 645, 143-164.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | PLCbeta1 | Homo sapiens | 5634 | - |
| nucleus | PLCbeta1 | Mus musculus | 5634 | - |
| nucleus | PLCbeta1 | Rattus norvegicus | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | required | Homo sapiens |  |
| Ca2+ | required | Mus musculus | |
| Ca2+ | required | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9NQ66 | PLCbeta1a and PLCbeta1b | - |
| Mus musculus | Q9Z1B3 | PLCbeta1a and PLCbeta1b | - |
| Rattus norvegicus | P10687 | PLCbeta1a and PLCbeta1b | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| preparation of nuclei, method development | Homo sapiens |
| preparation of nuclei, method development | Mus musculus |
| preparation of nuclei, method development | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| 3T3-L1 cell | - |
Mus musculus | - |
| C2C12 cell | - |
Mus musculus | - |
| MCF-7 cell | - |
Homo sapiens | - |
| NIH-3T3 cell | - |
Mus musculus | - |
| SAOS-2 cell | - |
Homo sapiens | - |
| Swiss-3T3 cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Homo sapiens | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
| 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Mus musculus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
| 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Rattus norvegicus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phosphoinositide-specific phospholipase C beta1 | - |
Homo sapiens |
| phosphoinositide-specific phospholipase C beta1 | - |
Mus musculus |
| phosphoinositide-specific phospholipase C beta1 | - |
Rattus norvegicus |
| PLCbeta1 | - |
Homo sapiens |
| PLCbeta1 | - |
Mus musculus |
| PLCbeta1 | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.7 | - |
assay at | Homo sapiens |
| 6.7 | - |
assay at | Mus musculus |
| 6.7 | - |
assay at | Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | possible involvement of the interstitial deletion of PLCbeta1 gene in the progression of myelodysplastic syndrome to acute myeloid leukemia in humans | Homo sapiens |
| additional information | method development for preparation of highly purified nuclei and the subsequent analysis of nuclear PLCbeta1 signaling, overview | Homo sapiens |
| additional information | method development for preparation of highly purified nuclei and the subsequent analysis of nuclear PLCbeta1 signaling, overview | Mus musculus |
| additional information | method development for preparation of highly purified nuclei and the subsequent analysis of nuclear PLCbeta1 signaling, overview | Rattus norvegicus |
| physiological function | nuclear PLCbeta1 is a key player in the control of cell cycle progression and has a key role as a check point in the G1 phase of the cell cycle, in fact it appears to be involved in the cyclin-mediated regulation of the physiological machinery | Homo sapiens |
| physiological function | nuclear PLCbeta1 is a key player in the control of cell cycle progression and has a key role as a check point in the G1 phase of the cell cycle, in fact it appears to be involved in the cyclin-mediated regulation of the physiological machinery | Mus musculus |
| physiological function | nuclear PLCbeta1 is a key player in the control of cell cycle progression and has a key role as a check point in the G1 phase of the cell cycle, in fact it appears to be involved in the cyclin-mediated regulation of the physiological machinery | Rattus norvegicus |
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Release 2023.1 (January 2023)
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