Application | Comment | Organism |
---|---|---|
pharmacology | showing that pharmacological inhibition of PLC enhances intestinal Ca2+ transport. This raises the possibility that pharmacological tools targeting PLC can be used to enhance intestinal Ca2+ absorption. Given the prevalence of osteoporosis, which generally comes with negative Ca2+ balance, PLC can be a clinically relevant pharmacological target in the future | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione | U73122, also inhibits Ca2+-induced inactivation of TRPV6 | Homo sapiens | |
edelfosine | ET-18-OCH3, also inhibits Ca2+-induced inactivation of TRPV6 | Homo sapiens | |
additional information | inactive analog U73343 also used | Homo sapiens | |
U-73122 | PLC inhibitor inhibits Ca2+-induced inactivation of TRPV6 in patch-clamp experiments | Homo sapiens | |
U-73343 | inactive analog of U-73122 | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | Ca2+ flowing activates phospholipase C leading to the depletion of phosphatidylinositol 4,5-bisphosphate and formation of inositol 1,4,5-trisphosphate in TRPV6-expressing cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
intestine | TRPV6-expressing cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylinositol 4,5-bisphosphate | demonstration of the role of PLC in Ca2+-induced inactivation of TRPV6 | Homo sapiens | inositol 1,4,5-trisphosphate | - |
? |