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Literature summary for 3.1.4.11 extracted from

  • Grubb, D.R.; Vasilevski, O.; Huynh, H.; Woodcock, E.A.
    The extreme C-terminal region of phospholipase Cbeta1 determines subcellular localization and function; the b splice variant mediates alpha1-adrenergic receptor responses in cardiomyocytes (2008), FASEB J., 22, 2768-2774.
    View publication on PubMed
Search for more literature for 3.1.4.11

Protein Variants

Protein Variants Comment Organism
additional information deletion of 3 amino acids from the C terminus of PLCbeta1b does not alter its sarcolemmal localization, but deletion of the entire unique 31 amino acid sequence causes cytosolic localization Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
caveola PLCbeta1b targets to the sarcolemma and is enriched in caveolae Rattus norvegicus 5901
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cytoplasm PLCbeta1a is localized in the cytoplasm Rattus norvegicus 5737
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additional information deletion of 3 amino acids from the C terminus of PLCbeta1b does not alter its sarcolemmal localization, but deletion of the entire unique 31 amino acid sequence causes cytosolic localization. PLCbeta1a expression is lost during postnatal development Rattus norvegicus
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sarcolemma PLCbeta1b targets to the sarcolemma and is enriched in caveolae Rattus norvegicus 42383
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
140000
-
 two splice variants, PLCbeta1a (150 kDa) and PLCbeta1b (140 kDa). Western Blot Rattus norvegicus
150000
-
 two splice variants, PLCbeta1a (150 kDa) and PLCbeta1b (140 kDa). Western Blot Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P10687 Sprague-Dawley rats
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Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
 Rattus norvegicus
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myocyte neonatal rat ventricular myocyte, NRVM Rattus norvegicus
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Synonyms

Synonyms Comment Organism
phospholipase Cbeta1
-
 Rattus norvegicus
PLCbeta1 two splice variants, PLCbeta1a and PLCbeta1b Rattus norvegicus