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Literature summary for 3.1.4.11 extracted from

  • Liu, X.; Zhao, Q.; Araki, S.; Zhang, S.; Miao, J.
    Contrasting effects of phosphatidylinositol- and phosphatidylcholine-specific phospholipase C on apoptosis in cultured endothelial cells (2006), Endothelium, 13, 205-211.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
48/80 compound 48/80, oligomeric mixture of condensation products of N-methyl-p-methoxyphenethylamine and formaldehyde Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens suppression of Pi-PLC promotes apoptosis of vascular endothelial cells by inhibiting phosphorylation of Akt, elevating P53 expression, and affecting the cell cycle distribution. phosphatidyl-specific phospholipase C and phosphatidylcholine-specific phospholipase C might control the apoptosis by jointly regulating akt phosphorylation, P53 expression and affecting cell cycle in vascular endothelial cells ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information suppression of Pi-PLC promotes apoptosis of vascular endothelial cells by inhibiting phosphorylation of Akt, elevating P53 expression, and affecting the cell cycle distribution. phosphatidyl-specific phospholipase C and phosphatidylcholine-specific phospholipase C might control the apoptosis by jointly regulating akt phosphorylation, P53 expression and affecting cell cycle in vascular endothelial cells Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
PI-PLC
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Homo sapiens