Protein Variants | Comment | Organism |
---|---|---|
Y1217F | phosphorylation site mutant | Homo sapiens |
Y753F | phosphorylation site mutant | Homo sapiens |
Y759F | phosphorylation site mutant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | LY294002 inhibits the BCR-induced PLC activation in Ramos cells in a dose-dependent manner | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P16885 | - |
- |
Mus musculus | - |
- |
- |
Mus musculus | Q8CIH5 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | PLC-gamma2 is phosphorylated on Y753, Y759, and Y1271 in response to engagement of the B-cell receptor in Ramos cells. In Ramos cells stimulated maximally with this receptor, the extent of phosphorylation of Y1217 is three times that of Y753 or of Y759. Stimulation of Jurkat cells or platelets via their immunoreceptors elicites phosphorylation of Y753 and Y759 but not that of Y1217. A basal level of phosphorylation of Y753 is apparent in unstimulated lymphocytes. The extent of phosphorylation of Y753 and Y759, but not that of Y1217 correlates with the lipase activity of PLC-gamma2. Btk is largely, but not completely, responsible for phosphorylation of Y753 and Y759, whereas phosphorylation of Y1217 is independent of Btk. Phosphorylation of Y1217 and that of Y753 and Y759 occurs on different PLC-gamma2 molecules | Homo sapiens |
phosphoprotein | PLC-gamma2 is phosphorylated on Y753, Y759, and Y1271 in response to engagement of the B-cell receptor in spleenic cells. In spleenic cells stimulated maximally with this receptor, the extent of phosphorylation of Y1217 is three times that of Y753 or of Y759 | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Homo sapiens | - |
JURKAT cell | - |
Homo sapiens | - |
Ramos cell | - |
Homo sapiens | - |
spleen | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Homo sapiens | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Mus musculus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phospholipase C-gamma2 | - |
Mus musculus |
phospholipase C-gamma2 | - |
Homo sapiens |
PLC-gamma2 | - |
Mus musculus |
PLC-gamma2 | - |
Homo sapiens |