Cloned (Comment) | Organism |
---|---|
expression in COS-7 cells | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
H503A | mutant enzyme shows reduced affinity for phosphoinositide binding and reduced hydrolysis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | Rattus norvegicus |
P500A | mutant enzyme shows reduced affinity for phosphoinositide binding and reduced hydrolysis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
expression in COS-7 cells | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | amino acids Pro500 and His503 are critical for binding of PLC-gamma1 to one of its substrates, 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate in the membrane | Rattus norvegicus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phospholipase C | - |
Rattus norvegicus |
PLC-gamma1 | - |
Rattus norvegicus |