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Literature summary for 3.1.4.11 extracted from
- Properties and distribution of phosphatidylinositol-specific phospholipase C in human and horse platelets (1983), Biochim. Biophys. Acta, 752, 329-338.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| deoxycholate | weak inhibition. Concentration of 2 mM inhibits the phospholipase C activity in all fractions by 20-30% | Equus caballus |  |
| deoxycholate | weak inhibition. Concentration of 2 mM inhibits the phospholipase C activity in all fractions by 20-30% | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.1 | 0.15 | 1-phosphatidyl-1D-myo-inositol | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | enzyme is predominantly localized in the soluble fraction | Homo sapiens | - |
- |
| additional information | enzyme is predominantly localized in the soluble fraction | Equus caballus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent on | Homo sapiens | |
| Ca2+ | dependend on | Equus caballus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Equus caballus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | homogenates, total particulate and soluble fractions | Homo sapiens | - |
| blood platelet | homogenates, total particulate and soluble fractions | Equus caballus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-phosphatidyl-1D-myo-inositol | - |
Equus caballus | 1D-myo-inositol 1-phosphate + diacylglycerol | in almost equal amounts with 1D-myo-inositol 1,2-cyclic phosphate | ? | |
| 1-phosphatidyl-1D-myo-inositol + H2O | - |
Homo sapiens | 1D-myo-inositol 1-phosphate + diacylglycerol | in almost equal amounts with 1D-myo-inositol 1,2-cyclic phosphate | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phospholipase C | - |
Homo sapiens |
| phospholipase C | - |
Equus caballus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | - |
- |
Homo sapiens |
| 5.5 | - |
- |
Equus caballus |
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Release 2023.1 (January 2023)
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