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Literature summary for 3.1.4.11 extracted from

  • Dawson, R.M.C.; Hemington, N.; Irvine, R.F.
    The inhibition of diacylglycerol-stimulated intracellular phospholipases by phospholipids with a phosphocholine-containing polar group. A possible physiological role for sphingomyelin (1985), Biochem. J., 230, 61-68.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.11

Activating Compound

Activating Compound Comment Organism Structure
diacylglycerol 5-6fold stimulation of rat brain phosphatidylinositol phosphodiesterase. The addition of choline phospholipids containing two long hydrophobic chains or choline lysophospholipids containing one long hydrophobic chain produced a total inhibition of the activation which had been produced by diacylglycerol Rattus norvegicus
diacylglycerol the addition of choline phospholipids containing two long hydrophobic chains or choline lysophospholipids containing one long hydrophobic chain produced a total inhibition of the activation which had been produced by diacylglycerol Homo sapiens
phosphatidylethanolamine activates the hydrolysis. Human platelet phosphatidylinositol phosphodiesterase Homo sapiens
phosphatidylethanolamine activates the hydrolysis. Human platelet phosphatidylinositol phosphodiesterase Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
choline plasmalogen 18.5% of choline plasmalogen is needed for 50% inhibition Homo sapiens
choline plasmalogen 18.5% of choline plasmalogen is needed for 50% inhibition Rattus norvegicus
lysocholine plasmalogen 8.5% of choline plasmalogen is needed for 50% inhibition Homo sapiens
lysocholine plasmalogen 8.5% of choline plasmalogen is needed for 50% inhibition Rattus norvegicus
lysophosphatidylcholine 50% inhibition is produced by 7% molar Homo sapiens
lysophosphatidylcholine 50% inhibition is produced by 7% molar Rattus norvegicus
additional information enzyme is substantially inhibited by all phospholipids containing a phosphocholine head group. The sphingosine-containing phospholipids are the most inhibitory; phosphatidic acid does not inhibit Homo sapiens
additional information enzyme is substantially inhibited by all phospholipids containing a phosphocholine head group. The sphingosine-containing phospholipids are the most inhibitory; phosphatidic acid does not inhibit Rattus norvegicus
oleoyl sphingomyelin
-
 Homo sapiens
oleoyl sphingomyelin
-
 Rattus norvegicus
phosphatidylcholine low effect, 50% inhibition is produced by 18% molar egg phosphatidylcholine Homo sapiens
phosphatidylcholine little effect, 50% inhibition is produced by 18% molar egg phosphatidylcholine Rattus norvegicus
sphingomyelin 50% inhibition at 6.5% molar, and 97% at 20% molar Homo sapiens
sphingomyelin 50% inhibition at low concentration, and 97% at high concentration Rattus norvegicus
sphingosylphosphocholine
-
 Homo sapiens
sphingosylphosphocholine
-
 Rattus norvegicus
stearoyl sphingomyelin
-
 Homo sapiens
stearoyl sphingomyelin
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Homo sapiens
-
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylinositol + H2O
-
 Rattus norvegicus 1D-myo-inositol 1-phosphate + diacylglycerol in vitro also inositol cyclic monophosphate formed ?
phosphatidylinositol + H2O
-
 Homo sapiens 1D-myo-inositol 1-phosphate + diacylglycerol in vitro myo-inositol 1,2-cyclic phosphate also formed ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol phosphodiesterase
-
 Homo sapiens
phosphatidylinositol phosphodiesterase
-
 Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 brain enzyme Rattus norvegicus
7.4
-
 platelet enzyme Homo sapiens