Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required, maximal hydrolysis of phosphatidylinositol 4,5-diphosphate at 0.004 mM, maximal hydrolysis of phosphatidylinositol at 0.5 mM | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
110000 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | plays a critical role in signal transduction in the receptor-activated human platelets | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
enzyme from platelet membrane | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
platelet | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.5784 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | plays a critical role in signal transduction in the receptor-activated human platelets | Homo sapiens | ? | - |
? | |
phosphatidylinositol + H2O | - |
Homo sapiens | ? | - |
? | |
phosphatidylinositol 4,5-bisphosphate + H2O | preferentially hydrolyzed | Homo sapiens | D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
hydrolysis of phosphatidylinositol 4,5-bisphosphate, in presence of sodium deoxycholate, enzyme from plasma membrane | Homo sapiens |
7.3 | - |
hydrolysis of phosphatidylinositol 4,5-bisphosphate, in presence of sodium deoxycholate, enzyme from cytoplasm | Homo sapiens |