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Literature summary for 3.1.4.11 extracted from

  • Banno, Y.; Nozawa, Y.
    Characterization of partially purified phospholipase C from human platelet membranes (1987), Biochem. J., 248, 95-101.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
membrane
-
Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required, maximal hydrolysis of phosphatidylinositol 4,5-diphosphate at 0.004 mM, maximal hydrolysis of phosphatidylinositol at 0.5 mM Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
110000
-
gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens plays a critical role in signal transduction in the receptor-activated human platelets ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
enzyme from platelet membrane Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
platelet
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.5784
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information plays a critical role in signal transduction in the receptor-activated human platelets Homo sapiens ?
-
?
phosphatidylinositol + H2O
-
Homo sapiens ?
-
?
phosphatidylinositol 4,5-bisphosphate + H2O preferentially hydrolyzed Homo sapiens D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
hydrolysis of phosphatidylinositol 4,5-bisphosphate, in presence of sodium deoxycholate, enzyme from plasma membrane Homo sapiens
7.3
-
hydrolysis of phosphatidylinositol 4,5-bisphosphate, in presence of sodium deoxycholate, enzyme from cytoplasm Homo sapiens