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Literature summary for 3.1.4.1 extracted from

  • Lee, S.Y.; Kim, H.; Hwang, H.J.; Jeong, Y.M.; Na, S.H.; Woo, J.C.; Kim, S.G.
    Identification of tyrosyl-DNA phosphodiesterase as a novel DNA damage repair enzyme in Arabidopsis (2010), Plant Physiol., 154, 1460-1469.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene At5g15170 or AtTDP, DNA and amino acid sequence determination and analysis, expression of GFP-tagged AtTDP in Arabidopsis thaliana plants Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information loss-of-function AtTDP mutation , genomic structure of the tdp T-DNA insertion mutant, overview. The tdp Dwarf mutant is caused by reduced cell numbers, phenotype, overview Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Arabidopsis thaliana 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Arabidopsis thaliana AtTDP has Tyr-phosphodiesterase activity for the topoisomerase-DNA complex ?
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q8H1D9 gene At5g15170 or AtTDP
-
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information AtTDP has Tyr-phosphodiesterase activity for the topoisomerase-DNA complex Arabidopsis thaliana ?
-
?

Synonyms

Synonyms Comment Organism
TDP1
-
Homo sapiens
TDP1
-
Arabidopsis thaliana
tyrosyl-DNA phosphodiesterase 1
-
Homo sapiens
tyrosyl-DNA phosphodiesterase 1
-
Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction a loss-of-function AtTDP mutation displays developmental defects and dwarf phenotype in Arabidopsis. This phenotype is substantially caused by decreased cell numbers without any change of individual cell sizes. The tdp plants exhibit hypersensitivities to camptothecin, a potent topoisomerase I inhibitor, and show rigorous cell death in cotyledons and rosette leaves, suggesting the failure of DNA damage repair in tdp mutants Arabidopsis thaliana
malfunction mutations of the Tdp1 gene are involved in the disease spinocerebellar ataxia with axonal neuropathy Homo sapiens
physiological function AtTDP plays a clear role in the repair of topoisomerase I-DNA complexes in Arabidopsis, the tyrosyl-DNA phosphodiesterase 1 is a key enzyme that hydrolyzes the phosphodiester bond between tyrosine of topoisomerase and 3'-phosphate of DNA and repairs topoisomerase-mediated DNA damage during chromosome metabolism. Recombinant AtTDP protein certainly hydrolyzes the 3'-phosphotyrosyl DNA substrates related to repairing in vivo topoisomerase I-DNA-induced damage Arabidopsis thaliana
physiological function tyrosyl-DNA phosphodiesterase 1 is a key enzyme that hydrolyzes the phosphodiester bond between tyrosine of topoisomerase and 3'-phosphate of DNA and repairs topoisomerase-mediated DNA damage during chromosome metabolism Homo sapiens