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Literature summary for 3.1.4.1 extracted from

  • Interthal, H.; Champoux, J.J.
    Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1 (2011), Biochem. J., 436, 559-566.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.1

Activating Compound

Activating Compound Comment Organism Structure
additional information processing by the proteasome is required for TDP1 cleavage in vivo Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens tyrosyl-DNA phosphodiesterase 1 catalyses the hydrolysis of phosphodiester linkages between a DNA 3' phosphate and a tyrosine residue as well as a variety of other DNA 3 substituents, the enzyme shows affinity for the substrate increased as the DNA length ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information tyrosyl-DNA phosphodiesterase 1 catalyses the hydrolysis of phosphodiester linkages between a DNA 3' phosphate and a tyrosine residue as well as a variety of other DNA 3 substituents, the enzyme shows affinity for the substrate increased as the DNA length Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
TDP1
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 Homo sapiens
tyrosyl-DNA phosphodiesterase 1
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 Homo sapiens

General Information

General Information Comment Organism
physiological function tyrosyl-DNA phosphodiesterase 1 catalyses the hydrolysis of phosphodiester linkages between a DNA 3' phosphate and a tyrosine residue as well as a variety of other DNA 3 substituents, and is implicated in the repair of covalent complexes involving eukaryotic type IB topoisomerases. Processing by the proteasome is required for TDP1 cleavage in vivo Homo sapiens