Protein Variants | Comment | Organism |
---|---|---|
additional information | Pde1c-/- and Pde4a-/- knockout mutants to examine the role of the PDEs in olfactory transduction. Pde1c-/- OSNs (olfactory sensory neuron cilia) show reduced sensitivity and attenuated adaptation to repeated stimulation, suggesting that PDE1C may be involved in regulating sensitivity and adaptation | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+/calmodulin | increased activity ca. 2.3fold | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
olfactory sensory neuron | OSN cilia, PDE1C is detected primarily in the cilial layer, whereas PDE4A is detected in OSN cell bodies, dentrites and axons. The loss of one of the PDEs does not effect the occurrence of the other PDE. The localization of the PDE4A protein is normal in PDE1c-/- knockout mutant mice and vice versa | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
no basal activity is detected using the Pde1-/- knockout mutant in the standard assay and also the addition of Ca2+/calmodulin does not elicit any PDE acitivty | Mus musculus |
0.0015 | - |
wild-type protein, in the absence of Ca2+, reflecting the basal PDE activity in the cilia, 37°C, pH not specified in the publication | Mus musculus |
0.0034 | - |
wild-type cilial PDE, supplemented with Ca2+ and calmodulin, 2.3fold increased compared compared to the assay without Ca2+, 37°C, pH not specified in the publication | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
PDE1C | - |
Mus musculus |
PDE4A | - |
Mus musculus |
phosphodiesterase 1C | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | Pde1c-/- and Pde4a-/- knockout mutants to examine the role of the PDEs in olfactory transduction. Pde1c-/- OSNs (olfactory sensory neuron cilia) show reduced sensitivity and attenuated adaptation to repeated stimulation, suggesting that PDE1C may be involved in regulating sensitivity and adaptation | Mus musculus |