Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-[3-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione | - |
Bothrops atrox | |
5-[3-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione | - |
Homo sapiens | |
5-[3-hydroxyphenyl]-1,3,4-oxadiazole-2(3H)-thione | - |
Bothrops atrox | |
5-[4-(t-butyldimethylsilyloxy)-phenyl]-1,3,4-oxadiazole-2(3H)-thione | - |
Bothrops atrox | |
5-[4-(t-butyldimethylsilyloxy)-phenyl]-1,3,4-oxadiazole-2(3H)-thione | - |
Homo sapiens | |
5-[4-(t-butyldimethylsilyloxy)-phenyl]-1,3,4-thiadiazole-2(3H)-thione | - |
Bothrops atrox | |
5-[4-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione | - |
Bothrops atrox | |
5-[4-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione | - |
Homo sapiens | |
5-[4-benzyloxyphenyl]-3-octyl-1,3,4-oxadiazole-2(3H)-thione | - |
Bothrops atrox | |
5-[4-hydroxyphenyl]-1,3,4-oxadiazole-2(3H)-thione | - |
Bothrops atrox | |
5-[4-hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione | - |
Bothrops atrox | |
5-[4-hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione | - |
Homo sapiens | |
5-[4-pyridyl]-1,3,4-oxadiazole-2(3H)-thione | - |
Bothrops atrox | |
5-[4-pyridyl]-1,3,4-thiadiazole-2(3H)-thione | - |
Bothrops atrox | |
5-[4-pyridyl]-1,3,4-thiadiazole-2(3H)-thione | - |
Homo sapiens | |
bis(1,3,4-oxadiazol-2-methyl)-5-thione | - |
Bothrops atrox | |
bis(1,3,4-oxadiazol-2-propyl)-5-thione | - |
Bothrops atrox | |
bis(1,3,4-oxadiazol-2-propyl)-5-thione | - |
Homo sapiens | |
bis(1,3,4-thiadiazole-2-methyl)-5-thione | - |
Bothrops atrox | |
EDTA | - |
Bothrops atrox | |
EDTA | - |
Homo sapiens | |
L-cysteine | - |
Bothrops atrox | |
L-cysteine | - |
Homo sapiens | |
additional information | the enzyme is not inhibited by 5-[4-pyridyl]-1,3,4-oxadiazole-2(3H)-thione, 5-[3-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione, 5-[4-benzyloxyphenyl]-3-octyl-1,3,4-oxadiazole-2(3H)-thione, 5-[4-benzyloxyphenyl]-3-benzyl-1,3,4-oxadiazole-2(3H)-thione, 5-[4-benzyloxyphenyl]-3-pentyl-1,3,4-oxadiazole-2(3H)-thione, 5-cyclohexyl-1,3,4-oxadiazole-2(3H)-thione, 5-diphenylmethyl-1,3,4-oxadiazole-2(3H)-thione, 5-[4-benzyloxyphenyl]-3-benzoyl-1,3,4-oxadiazole-2(3H)-thione, 5-[4-benzyloxyphenyl]-3-(2-hydroxyethyl)-1,3,4-oxadiazole-2(3H)-thione, 5-[1-naphthyl]-1,3,4-oxadiazole-2(3H)-thione, 5-phenyl-1,3,4-thiadiazole-2(3H)-thione, 5-[4-hydroxyphenyl]-3-benzyl-1,3,4-thiadiazole-2(3H)-thione, 5-[4-propoxyphenyl]-3-propyl-1,3,4-thiadiazole-2(3H)-thione, 5-diphenylmethyl-1,3,4-thiadiazole-2(3H)-thionr, 5-[4-hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione, and 5-[4-benzyloxyphenyl]-3-benzyl-1,3,4-thiaadiazole-2(3H)-thione | Bothrops atrox | |
additional information | the enzyme is not inhibited by bis(1,3,4-oxadiazol-2-methyl)-5-thione, 5-[4-pyridyl]-1,3,4-oxadiazole-2(3H)-thione, 5-[3-hydroxyphenyl]-1,3,4-oxadiazole-2(3H)-thione, 5-[4-benzyloxyphenyl]-3-octyl-1,3,4-oxadiazole-2(3H)-thione, and 5-[4-(t-butyldimethylsilyloxy)-phenyl]-1,3,4-thiadiazole-2 (3H)-thione | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bothrops atrox | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Bothrops atrox | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phenyl phosphonate + H2O | - |
Homo sapiens | 4-nitrophenol + phenyl phosphonate | - |
? | |
bis(4-nitrophenyl) phosphate + H2O | - |
Bothrops atrox | 4-nitrophenyl phosphate + 4-nitrophenol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NPP1 | - |
Homo sapiens |
NPP1 | - |
Bothrops atrox |
nucleotide pyrophosphatase/phosphodiesterase 1 | - |
Homo sapiens |
nucleotide pyrophosphatase/phosphodiesterase 1 | - |
Bothrops atrox |
PC-1 | - |
Homo sapiens |
PC-1 | - |
Bothrops atrox |
phosphodiesterase 1 | - |
Homo sapiens |
phosphodiesterase 1 | - |
Bothrops atrox |
plasma cell membrane glycoprotein | - |
Homo sapiens |
plasma cell membrane glycoprotein | - |
Bothrops atrox |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.15 | - |
bis(1,3,4-oxadiazol-2-propyl)-5-thione | in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C | Homo sapiens | |
0.36 | - |
5-[4-(t-butyldimethylsilyloxy)-phenyl]-1,3,4-oxadiazole-2(3H)-thione | in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C | Homo sapiens | |
0.36 | - |
5-[3-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione | in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C | Homo sapiens | |
0.85 | - |
5-[4-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione | in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C | Homo sapiens | |
0.85 | - |
5-[4-hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione | in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.06647 | - |
in Tris-HCl buffer 33 mM pH 8.8, at 37°C | Bothrops atrox | 5-[4-(t-butyldimethylsilyloxy)-phenyl]-1,3,4-thiadiazole-2(3H)-thione | |
0.274 | - |
in Tris-HCl buffer 33 mM pH 8.8, at 37°C | Bothrops atrox | EDTA | |
0.368 | - |
in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C | Homo sapiens | 5-[4-(t-butyldimethylsilyloxy)-phenyl]-1,3,4-oxadiazole-2(3H)-thione | |
0.368 | - |
in Tris-HCl buffer 33 mM pH 8.8, at 37°C | Bothrops atrox | 5-[4-(t-butyldimethylsilyloxy)-phenyl]-1,3,4-oxadiazole-2(3H)-thione | |
0.39 | - |
in Tris-HCl buffer 33 mM pH 8.8, at 37°C | Bothrops atrox | 5-[4-hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione | |
0.429 | - |
in Tris-HCl buffer 33 mM pH 8.8, at 37°C | Bothrops atrox | bis(1,3,4-oxadiazol-2-propyl)-5-thione | |
0.467 | - |
in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C | Homo sapiens | bis(1,3,4-oxadiazol-2-propyl)-5-thione | |
0.494 | - |
in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C | Homo sapiens | 5-[3-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione | |
0.628 | - |
in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C | Homo sapiens | 5-[4-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione | |
0.66 | - |
in Tris-HCl buffer 33 mM pH 8.8, at 37°C | Bothrops atrox | 5-[4-pyridyl]-1,3,4-thiadiazole-2(3H)-thione | |
0.748 | - |
in Tris-HCl buffer 33 mM pH 8.8, at 37°C | Bothrops atrox | L-cysteine | |
0.839 | - |
in Tris-HCl buffer 33 mM pH 8.8, at 37°C | Bothrops atrox | bis(1,3,4-thiadiazole-2-methyl)-5-thione | |
0.85 | - |
in Tris-HCl buffer 33 mM pH 8.8, at 37°C | Bothrops atrox | bis(1,3,4-oxadiazol-2-methyl)-5-thione | |
0.9 | - |
in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C | Homo sapiens | 5-[4-hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione | |
0.9 | - |
in Tris-HCl buffer 33 mM pH 8.8, at 37°C | Bothrops atrox | 5-[4-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione | |
0.96 | - |
in Tris-HCl buffer 33 mM pH 8.8, at 37°C | Bothrops atrox | 5-[4-hydroxyphenyl]-1,3,4-oxadiazole-2(3H)-thione | |
0.998 | - |
in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C | Homo sapiens | 5-[4-pyridyl]-1,3,4-thiadiazole-2(3H)-thione | |
1 | - |
in Tris-HCl buffer 33 mM pH 8.8, at 37°C | Bothrops atrox | 5-[3-hydroxyphenyl]-1,3,4-oxadiazole-2(3H)-thione |